Category: Original Article, DOI: Recived: 29/10/2024, Accepted: 12/12/2024, Published online: 29/12/2024
Santosh Prasad1, Shweta2*
Background: Exercise tolerance and oxygen saturation are two of the most important parameters in the evaluation and management of mild-moderate asthma. The aim of this study was to study exercise and examine oxygen saturation profiles during standardised exercise testing in patients with asthma. Method: This was a prospective observational study conducted over 12 months, and 128 patients (57% male; mean age = 42.3±13.7 years) with mild to moderate asthma participated. Baseline spirometry, a six-minute walk test (6MWT) with continuous oxygen saturation measurement, and completion of the Asthma Quality of Life Questionnaire (AQLQ) form the preassessment. The exercise parameters, pulmonary function, and quality of life measures have been analysed using descriptive statistics, correlation, and multiple regression. Results: The average distance covered by the 6-min. walk test was 423.5 m with a standard deviation of 68.7 m during which there was significant oxygen desaturation (SpO2 drop from 97.2±1.3% to 94.8±2.1%) while exercising. A strong correlation was established between 6MWT distance and FEV1 and between exercise parameters and quality of life scores (r=0.68, p<0.001 and r=0.62, p<0.001 respectively). Multiple regression analysis revealed that FEV1 % predicted (?=0.42, p<0.001) and AQLQ score (?=0.35, p<0.001) were independent significant predictors of exercise tolerance. The quality of life assessment showed that all domains were moderately impacted, with the domain with the highest mean score being emotional function at 5.4±1.0 and activity limitation at the lowest of 4.8±1.3. Conclusions: Patients with mild to moderate asthma exhibited a strong correlation between exercise tolerance and pulmonary function or quality of life indicators. Monitoring oxygen saturation during exercise can provide an understanding of functional limitations and may be helpful for future asthma management.
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Prasad S., Shweta (2024). Clinical Analysis of Exercise Tolerance and Oxygen Saturation Levels in Patients with Mild-Moderate Asthma: A Comprehensive Study. International Journal of Multidisciplinary Health Sciences and Research, 2(4),01-09.
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